Education

• B.S., Dept. of Animal Science and Biotechnology, Seoul National University, 1998
• M.S., Dept. of Animal Science and Biotechnology, Seoul National University, 2000
• Ph.D., Dept. of Animal Science, Center for Regenerative Biology, University of Connecticut, 2009

Professional Experiences

• Project leader, Institute of Drug Discovery, LG Life Sciences R&D Park, 2013.01-2016.08
    - Novel GPCR antagonist for anti-diabetes and anti-obesity
    - Cancer genomics in Korean patients with colon cancer
    - Knowledge-based approach on metabolic disorders
    - Computational drug repositioning
• Study Director, Drug Development Center, LG Life Sciences R&D Park, 2000.02-2012.12
    - Phase 1 IND approval of LC28-0126 for myocardial infarction, MFDS, Korea
    - NDA approval of Zemiglo for type 2 diabetes, MFDS, Korea
    - NDA approval of Factive for upper respiratory tract infection, ISP, Chile
    - GLP certificate of developmental and reproductive toxicology studies, KFDA, Korea

Society Memberships

• The Korea Society of Nonclinical Study (한국비임상시험연구회)
    - President (2024-present)
    - Academic director (2018-2019)
    - General affairs (2014-2015)

Research Interests

• Big data-driven therapeutic target discovery (빅데이터 기반 타겟 발굴)
• PROKR1 synthetic agonist to treat sarcopenia (근육질환)
• GPR39-G0S2 signaling in obesity (비만)
• Epigenetic target discovery in Hanwoo reproduction (후성유전)

Lectures

• Applied animal cell biology (동물세포학)
• Industrial development of pharmaceutical Ingredients (약리소재론)
• Biological research methodology using big data (빅데이터를 활용한 생물학 연구론)

Awards

• Best Project Award, LG Life Sciences, 2014
• Outstanding Graduate Student Award, Dept. of Animal Science, University of Connecticut, 2009
• Larry Ewing Memorial Trainee Travel Fund Scholarship, Society for the Study of Reproduction, 2009
• Graduate Research Award, College of Agriculture and Natural Resources Graduate Council Research Forum, University of Connecticut, 2007

Publications (selected)

• Park JH, Mok J, Park S, Kim D, Kang MS, Park TS, Park J. Celecoxib Enhances Oxidative Muscle Fibre Formation and Improves Muscle Functions Through Prokr1 Activation in Mice. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13704. doi: 10.1002/jcsm.13704. PMID: 39887895; PMCID: PMC11780397
• Jeong SY, Park BW, Kim J, Lee S, You H, Lee J, Lee S, Park JH, Kim J, Sim W, Ban K, Park J, Park HJ, Kim S. Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct. J Nanobiotechnology. 2024 Apr 4;22(1):149. doi: 10.1186/s12951-024-02410-x. PMID: 38570846; PMCID: PMC10993512
• Mok J, Park JH, Yeom SC, Park J. PROKR1-CREB-NR4A2 axis for oxidative muscle fiber specification and improvement of metabolic function. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2308960121. doi: 10.1073/pnas.2308960121. Epub 2024 Jan 17. PMID: 38232288; PMCID: PMC10823220
• Park JG, Lim DC, Park JH, Park S, Mok J, Kang KW, Park J. Benzbromarone Induces Targeted Degradation of HSP47 Protein and Improves Hypertrophic Scar Formation. J Invest Dermatol. 2024 Mar;144(3):633-644. doi: 10.1016/j.jid.2023.09.279. Epub 2023 Oct 13. PMID: 37838329
• Kim J, Lee SK, Jung M, Jeong SY, You H, Won JY, Han SD, Cho HJ, Park S, Park J, Kim TM, Kim S. Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice. J Nanobiotechnology. 2022 Dec 10;20(1):526. doi: 10.1186/s12951-022-01728-8. PMID: 36496385; PMCID: PMC9741801
• Kim J, Lee SK, Jeong SY, Cho HJ, Park J, Kim TM, Kim S. Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis. J Nanobiotechnology. 2021 Nov 17;19(1):372. doi: 10.1186/s12951-021-01120-y. PMID: 34789265; PMCID: PMC8600817
• Zhang C, Mok J, Seong Y, Lau HC, Kim D, Yoon J, Oh SW, Park TS, Park J. PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts. Nanomedicine. 2021 Oct;37:102448. doi: 10.1016/j.nano.2021.102448. Epub 2021 Jul 25. PMID: 34314870
• Kim SW, Kim B, Mok J, Kim ES, Park J. Dysregulation of the Acrosome Formation Network by 8-oxoguanine (8-oxoG) in Infertile Sperm: A Case Report with Advanced Techniques. Int J Mol Sci. 2021 May 30;22(11):5857. doi: 10.3390/ijms22115857. PMID: 34070710; PMCID: PMC8199233
• Kim ES, Kida K, Mok J, Seong Y, Jo SY, Kanaki T, Horikawa M, Kim KH, Kim TM, Park TS, Park J. Cellhesion VP enhances the immunomodulating potential of human mesenchymal stem cell-derived extracellular vesicles. Biomaterials. 2021 Apr;271:120742. doi: 10.1016/j.biomaterials.2021.120742. Epub 2021 Mar 1. PMID: 33706111
• Ku GW, Kang Y, Yu SL, Park J, Park S, Jeong IB, Kang MW, Son JW, Kang J. LncRNA LINC00240 suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p. BMC Cancer. 2021 Jan 9;21(1):44. doi: 10.1186/s12885-020-07755-8. PMID: 33422052; PMCID: PMC7796488
• Mok J, Park TS, Kim S, Kim D, Choi CS, Park J. Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle. FASEB J. 2021 Feb;35(2):e21179. doi: 10.1096/fj.202001641R. Epub 2020 Nov 13. PMID: 33184929